Transcatheter Therapies in Challenging Aortic Ailments

Transcatheter Aortic Valve Replacement: A Review Article

Transcatheter aortic valve replacement (TAVR) is a novel therapeutic intervention for the replacement of severely stenotic aortic valves in high-risk patients for standard surgical procedures. Since the initial PARTNER trial results, use of TAVR has been on the rise each year. New delivery methods and different valves have been developed and modified in order to promote the minimally invasive p...

Aortic root imaging in the era of transcatheter aortic valve implantation/transcatheter aortic valve replacement.

Transcatheter therapies for mitral regurgitation:

Recently, updates of both the European Society of Cardiology (ESC), as well as the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines on the management of patients with valvular heart disease (VHD) have been released [1,2]. Several important revisions were incorporated, which have the potential to fundamentally alter treatment for many patients. The most important ...

Transcatheter Aortic Valve Replacement

With the worldwide number of TAVR procedures rapidly approaching 200,000, coupled with an amassed knowledge spanning over a decade, we are able to now reflect on the evolution of TAVR and how changes in technology, operator/institution experience, and patient selection have ultimately affected clinical outcomes. With this in mind, in this issue of JACC: Cardiovascular Interventions, Beohar et a...

Targeted Therapies in Sarcomas: Challenging the Challenge

Sarcomas are a heterogeneous group of mesenchymal malignancies that very often lead to death. Nowadays, chemotherapy is the only available treatment for most sarcomas but there are few active drugs and clinical results still remain very poor. Thus, there is an imperious need to find new therapeutic alternatives in order to improve sarcoma patient's outcome. During the last years, there have bee...